Brucellosis seroprevalence in ovine and caprine flocks in China during 2000-2018: a systematic review and meta-analysis

Ran, X. and Chen, X. and Wang, M. and Cheng, J. and Ni, H. and Zhang, X. X. and Wen, X.

BMC Vet Res (2018) 14: 393

DOI: 10.1186/s12917-018-1715-6

Abstract

BACKGROUND: Brucellosis remains one of the most common zoonotic diseases globally, with more than half million human cases reported annually. Brucellosis is an emerging and re-emerging disease in China since the 1990s. An infectious reservoir constituted by domestic animals with brucellosis, especially ovine and caprine herds, poses a significant threat to public health. The seroprevalence of brucellosis in sheep and goat flocks in a national context is unavailable so far. Therefore, we conducted this systematic review and meta-analysis to assess the overall status of brucellosis in sheep and goats in China in almost two decades. RESULTS: The pooled prevalence of brucellosis in ovine and caprine flocks in China increased in 2000-2009 (1.00%; 95% CI, 0.70-1.30) to 2010-2018 (3.20%; 95% CI, 2.70-3.60). The seroprevalence of brucellosis in sheep and goat flocks was higher in Eastern China, with 7.00% of positive rate, than that in any other region, especially Shandong province (18.70%). Brucellosis is highly endemic in some local regions. The high prevalence of brucellosis in agricultural regions is suggestive of a shift of geographic distribution. The pooled prevalence of brucellosis is higher in goat flocks than in sheep flocks in China. CONCLUSIONS: The overall data in this meta-analysis demands comprehensive intervention measures and further surveillance to facilitate the control of brucellosis in livestock. Further studies aimed at evaluating the risk factors associated with spreads of brucellosis in domestic animals unaddressed so far, and sufficient epidemiological data is important to the exploration and understanding of the prevalent status of brucellosis throughout the country and to disease control.

Citation

Ran, X., Chen, X., Wang, M., Cheng, J., Ni, H., Zhang, X. X., & Wen, X. (2018). Brucellosis seroprevalence in ovine and caprine flocks in China during 2000-2018: a systematic review and meta-analysis. BMC Vet Res, 14(1), 393. https://doi.org/10.1186/s12917-018-1715-6 Animals, China, Prevalence, Sheep, Goats, Seroepidemiologic Studies, China/epidemiology, Meta-analysis, Systematic review, Brucellosis, Brucellosis/epidemiology/*veterinary, Goat Diseases/*epidemiology/microbiology, Sheep Diseases/*epidemiology/microbiology, affiliations., authors declare no competing interests. PUBLISHER’S NOTE: Springer Nature remains, neutral with regard to jurisdictional claims in published maps and institutional, Not Applicable. CONSENT FOR PUBLICATION: Not Applicable. COMPETING INTERESTS: The, Ovine and caprine

Keywords

• Animals
• China
• Prevalence
• Sheep
• Goats
• Seroepidemiologic Studies
• China/epidemiology
• Meta-analysis
• Systematic review
• Brucellosis
• Brucellosis/epidemiology/*veterinary
• Goat Diseases/*epidemiology/microbiology
• Sheep Diseases/*epidemiology/microbiology
• affiliations.
• authors declare no competing interests. PUBLISHER’S NOTE: Springer Nature remains
• neutral with regard to jurisdictional claims in published maps and institutional
• Not Applicable. CONSENT FOR PUBLICATION: Not Applicable. COMPETING INTERESTS: The
• Ovine and caprine