Systematic Review and Meta-Analysis of the Efficacy of MLC901 (NeuroAiD II(TM)) for Acute Ischemic Brain Injury in Animal Models

Ranuh, Igmar and Sari, G. M. and Utomo, B. and Suroto, N. S. and Fauzi, A. A.

J Evid Based Integr Med (2021) 26: 2515690x211039219

DOI: 10.1177/2515690x211039219

Abstract

INTRODUCTION: Moleac (MLC) 901 is a traditional Chinese medication approved by the Sino Food and Drug Administration in 2001 for treating stroke. This study aims to analyze the efficacy of MLC901 in animal stroke models after medial cerebral artery occlusion (MCAO). METHODS: Literature selection was performed according to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA) 2015. Inclusion criteria for the experimental studies were the use of animal models, publication in English between 1990 and 2020, information regarding the intervention technique used, and outcomes regarding the efficacy of MLC901 administration. RESULTS: MLC901 administration resulted in significantly less infarction volume by a mean difference of 17.17 compared to the control group (p \textless .00001). The MLC901 group resulted in significant improvement in 5-bromo-20-deoxyuridine (BrdU)-positive cells expression by a mean difference of 662.79 (p \textless .00001) and neurological function, which was indicated by a mean difference in the Bederson Neurological Outcome Score of 1.40 (p \textless .00001). CONCLUSIONS: MLC901 administration in an animal stroke model resulted in a better reduction in infarction volume and improvement in BrdU expression and neurologic function. These data could help in further determining the efficacy of MLC901 for acute ischemic brain injury in humans.

Citation

Ranuh, I., Sari, G. M., Utomo, B., Suroto, N. S., & Fauzi, A. A. (2021). Systematic Review and Meta-Analysis of the Efficacy of MLC901 (NeuroAiD II(TM)) for Acute Ischemic Brain Injury in Animal Models. J Evid Based Integr Med, 26, 2515690x211039219. https://doi.org/10.1177/2515690x211039219 Animals, Disease Models, Animal, Drugs, Chinese Herbal/*pharmacology, *ischemic stroke, article., of interest with respect to the research, authorship, and/or publication of this, Brain Injuries/*drug therapy, *Bederson Neurological Outcome Score, *BrdU expression, *infarction volume, *mlc901, Ischemic Stroke/*drug therapy, Middle Cerebral Artery/physiopathology

Keywords

• Animals
• Disease Models
• Animal
• Drugs
• Chinese Herbal/*pharmacology
• *ischemic stroke
• article.
• of interest with respect to the research
• authorship
• and/or publication of this
• Brain Injuries/*drug therapy
• *Bederson Neurological Outcome Score
• *BrdU expression
• *infarction volume
• *mlc901
• Ischemic Stroke/*drug therapy
• Middle Cerebral Artery/physiopathology