Seroprevalence estimates for toxocariasis in people worldwide: A systematic review and meta-analysis

Rostami, A. and Riahi, S. M. and Holland, C. V. and Taghipour, A. and Khalili-Fomeshi, M. and Fakhri, Y. and Omrani, V. F. and Hotez, P. J. and Gasser, R. B.

PLoS Negl Trop Dis (2019) 13: e0007809

DOI: 10.1371/journal.pntd.0007809

Abstract

BACKGROUND: Human toxocariasis is an important neglected disease. We performed a systematic review and meta-analysis study to estimate the global and regional prevalence of anti-Toxocara serum antibodies (referred to as ’T-seroprevalence’) in human populations around the world. METHODS: We searched five international databases (PubMed, EMBASE, Web of Science, SciELO and Scopus) for seroprevalence studies published from 1 January 1980 to 15 March 2019. We used random effect models to calculate the overall T-seroprevalence (with 95% CIs) in all six WHO regions and worldwide. We also conducted subgroup and linear meta-regression analyses to evaluate the impact of socio-demographic, geographical and climatic parameters on seroprevalence. RESULTS: We identified 250 eligible studies (253 datasets) comprising 265,327 participants in 71 countries for inclusion in the present meta-analysis. The estimated global T-seroprevalence rate was 19.0% (95%CI, 16.6-21.4%; 62,927/265,327); seroprevalence was highest in the African region (37.7%; 25.7-50.6%) and lowest in the Eastern Mediterranean region (8.2%; 5.1-12.0%). The pooled seroprevalence for other WHO regions was 34.1% (20.2-49.4%) in the South-East Asia; 24.2% (16.0-33.5%) in the Western Pacific; 22.8% (19.7-26.0%) in the American; and 10.5% (8.5-12.8%) in the European regions. A significantly higher T-seroprevalence was associated with a lower income level; lower human development index (HDI); lower latitude; higher humidity; higher temperature; and higher precipitation (P-value \textless 0.001). Potential risk factors associated with seropositivity to Toxocara included male gender; living in a rural area; young age; close contact with dogs, cats or soil; consumption of raw meat; and the drinking of untreated water. CONCLUSIONS: The present findings indicate high levels of infection with, or exposure to Toxocara spp. in many countries, which calls for increased attention to human toxocariasis and improved measures to prevent adverse health risks of this disease.

Citation

Rostami, A., Riahi, S. M., Holland, C. V., Taghipour, A., Khalili-Fomeshi, M., Fakhri, Y., Omrani, V. F., Hotez, P. J., & Gasser, R. B. (2019). Seroprevalence estimates for toxocariasis in people worldwide: A systematic review and meta-analysis. PLoS Negl Trop Dis, 13(12), e0007809. https://doi.org/10.1371/journal.pntd.0007809 Animals, Male, Adult, Aged, Aged, 80 and over, Female, Humans, Middle Aged, Adolescent, Child, Child, Preschool, Infant, Young Adult, Risk Factors, Global Health, Seroepidemiologic Studies, Infant, Newborn, Antibodies, Helminth/*blood, Toxocara/*immunology, Toxocariasis/*epidemiology

Keywords

• Animals
• Male
• Adult
• Aged
• Aged
• 80 and over
• Female
• Humans
• Middle Aged
• Adolescent
• Child
• Child
• Preschool
• Infant
• Young Adult
• Risk Factors
• Global Health
• Seroepidemiologic Studies
• Infant
• Newborn
• Antibodies
• Helminth/*blood
• Toxocara/*immunology
• Toxocariasis/*epidemiology