Effects of probiotics supplementation on dementia and cognitive impairment: a systematic review and meta-analysis of preclinical and clinical studies. (Special issue on the role of gut microbiota in the pathogenesis, diagnosis and treatment of psychiatric disorders.)

Ruiz-Gonzalez, C. and Roman, P. and Rueda-Ruzafa, L. and Rodriguez-Arrastia, M. and Cardona, D.

Progress in Neuro Psychopharmacology & Biological Psychiatry (2021) 108: 108

DOI: 10.1016/j.pnpbp.2020.110189

Abstract

Background: Dementia is a chronic syndrome characterized by cognitive and behavioral symptoms, which may include short-term memory impairment and problems related to orientation, language, attention and perception. Although cognitive impairment (CI) is increasingly considered the main geriatric condition predisposing to dementia, its early management could still promote symptomatic relief and delay disease progression . Recently, probiotics treatment has been studied as a potential new therapeutic approach to attenuate dementia-related decline and mild cognitive impairment (MCI). Therefore, we conducted a systematic review and meta-analysis to review and analyse the available evidence on the effect of probiotics on MCI and dementia.

Citation

Ruiz-Gonzalez, C., Roman, P., Rueda-Ruzafa, L., Rodriguez-Arrastia, M., & Cardona, D. (2021). Effects of probiotics supplementation on dementia and cognitive impairment: a systematic review and meta-analysis of preclinical and clinical studies. (Special issue on the role of gut microbiota in the pathogenesis, diagnosis and treatment of psychiatric disorders.). Progress in Neuro Psychopharmacology & Biological Psychiatry, 108, 108. https://doi.org/10.1016/j.pnpbp.2020.110189 meta-analysis, animal models, man, systematic reviews, human diseases, laboratory animals, disease models, food supplements, probiotics, cognition, Nutrition related Disorders and Therapeutic Nutrition [VV130], Non-communicable Human Diseases and Injuries [VV600], Lactobacillus, Animal Models of Human Diseases [VV400], mental disorders, mental illness, symptoms, dementia, Animal Models of Human Nutrition [VV140], medical treatment, chronic diseases, Bifidobacterium

Keywords

• meta-analysis
• animal models
• man
• systematic reviews
• human diseases
• laboratory animals
• disease models
• food supplements
• probiotics
• cognition
• Nutrition related Disorders and Therapeutic Nutrition [VV130]
• Non-communicable Human Diseases and Injuries [VV600]
• Lactobacillus
• Animal Models of Human Diseases [VV400]
• mental disorders
• mental illness
• symptoms
• dementia
• Animal Models of Human Nutrition [VV140]
• medical treatment
• chronic diseases
• Bifidobacterium