VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
One Health (2021) 12:
DOI: 10.1016/j.onehlt.2021.100236
Antimicrobial resistance (AMR) represents a major threat to human and animal health. Part of the AMR dimension is the circulation of extended-spectrum beta-lactamases producing-Escherichia coli (ESBL-E. coli), which is now commonly reported among companion animals. However, the global perspective of the prevalence and population structure of ESBL-E. coli circulating in dogs and cats has not been estimated limiting our understanding of their role in the dissemination of ESBL-E. coli. The aim of this study was to compare the prevalence of ESBL-E. coli between dogs and cats and across countries through meta-analysis. We also performed a scoping review to summarize the current knowledge on ESBL genes and E. coli clones circulating among companion animals. A total of 128 studies published in PubMed, Web of Science, and Scopus up to April 2020 were selected and contained information on prevalence and/or molecular characterization of ESBL genes and ESBL-E. coli clones. Our review shows an increase in the number of publications between 2000 and 2019, concentrated mainly in Europe. Prevalence varied across continents, ranging from 0.63% (Oceania) to 16.56% (Africa) in dogs and from 0% (Oceania) to 16.82% (Asia) in cats. Although there were twice as many studies reporting prevalence on dogs (n = 61) than on cats (n = 32), and only 9 studies focused exclusively on cats, our meta-analysis showed no difference in the global prevalence of ESBL-E. coli between dogs (6.87% [95% CI: 4.46-10.45%]) and cats (5.04% [95% CI: 2.42-10.22%]). A considerable diversity of ESBL genes (n = 60) and sequence types (ST) (n = 171) were recovered from companion animals. ESBL-E. coli encoded by CTX-M-15 (67.5%, 77/114) and SHV-12 (21.9%, 25/114), along with resistant strains of ST38 (22.7%, 15/66) and ST131 (50%, 33/66) were widespread and detected in all continents. While presence of ESBL-E. coli is widespread, the drivers influencing the observed ESBL-E. coli prevalence and the clinical relevance in veterinary medicine and public health along with economic impact of ESBL-E. coli infections among companion animals need to be further investigated.
Salgado-Caxito, M., Benavides, J. A., Adell, A. D., Paes, A. C., & Moreno-Switt, A. I. (2021). Global prevalence and molecular characterization of extended-spectrum beta-lactamase producing-Escherichia coli in dogs and cats - a scoping review and meta-analysis. One Health, 12. https://doi.org/10.1016/j.onehlt.2021.100236 Dogs, Cats, dogs, Prevalence, meta-analysis, Oceania, veterinary medicine, Europe, cats, data analysis, pet animals, pets, Pets and Companion Animals [LL070], research, studies, disease prevalence, epidemiology, Africa, drug resistance, Pesticide and Drug Resistance [HH410], public health, animal health, publications, Agricultural Economics [EE110], infections, genes, characterization, strains, Escherichia coli, Genetics and Molecular Biology of Microorganisms [ZZ395], Prion, Viral, Bacterial and Fungal Pathogens of Animals [LL821], Molecular Biology and Molecular Genetics [ZZ360], antiinfective agents, antimicrobials, economic impact, anti-microbial properties, antimicrobial properties, biochemical genetics, molecular genetics, E coli, Biochemistry and Physiology of Microorganisms [ZZ394], Taxonomy and Evolution [ZZ380], population structure, extended spectrum beta-lactamases