Efficacy of bacterial vaccines to prevent respiratory disease in swine: a systematic review and network meta-analysis

Sargeant, J. M. and Deb, B. and Bergevin, M. D. and Churchill, K. and Dawkins, K. and Dunn, J. and Hu, D. and Moody, C. and O’Connor, A. M. and O’Sullivan, T. L. and Reist, M. and Wang, C. and Wilhelm, B. and Winder, C. B.

Anim Health Res Rev (2019) 20: 274–290

DOI: 10.1017/s1466252319000173

Abstract

A systematic review and network meta-analysis (MA) was conducted to address the question, ’What is the efficacy of bacterial vaccines to prevent respiratory disease in swine?’ Four electronic databases and the grey literature were searched to identify clinical trials in healthy swine where at least one intervention arm was a commercially available vaccine for one or more bacterial pathogens associated with respiratory disease in swine, including Mycoplasma hyopneumoniae, Actinobacillus pleuropneumonia, Actinobacillus suis, Bordetella bronchiseptica, Pasteurella multocida, Stretococcus suis, Haemophils parasuis, and Mycoplasma hyorhinis. To be eligible, trials had to measure at least one of the following outcomes: incidence of clinical morbidity, mortality, lung lesions, or total antibiotic use. There were 179 eligible trials identified in 146 publications. Network MA was undertaken for morbidity, mortality, and the presence or absence of non-specific lung lesions. However, there was not a sufficient body of research evaluating the same interventions and outcomes to allow a meaningful synthesis of the comparative efficacy of the vaccines. To build this body of research, additional rigor in trial design and analysis, and detailed reporting of trial methods and results are warranted.

Citation

Sargeant, J. M., Deb, B., Bergevin, M. D., Churchill, K., Dawkins, K., Dunn, J., Hu, D., Moody, C., O’Connor, A. M., O’Sullivan, T. L., Reist, M., Wang, C., Wilhelm, B., & Winder, C. B. (2019). Efficacy of bacterial vaccines to prevent respiratory disease in swine: a systematic review and network meta-analysis. Anim Health Res Rev, 20(2), 274–290. https://doi.org/10.1017/s1466252319000173 Animals, Swine, *systematic review, Network Meta-Analysis, *respiratory disease, *Antibiotic use, *bacterial vaccines, *network meta-analysis, *swine, Bacterial Infections/prevention & control/*veterinary, Bacterial Vaccines/*immunology, Respiratory Tract Infections/microbiology/prevention & control/*veterinary, Swine Diseases/microbiology/*prevention & control

Keywords

• Animals
• Swine
• *systematic review
• Network Meta-Analysis
• *respiratory disease
• *Antibiotic use
• *bacterial vaccines
• *network meta-analysis
• *swine
• Bacterial Infections/prevention & control/*veterinary
• Bacterial Vaccines/*immunology
• Respiratory Tract Infections/microbiology/prevention & control/*veterinary
• Swine Diseases/microbiology/*prevention & control