VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Animals (Basel) (2021) 11:
DOI: 10.3390/ani11082245
In anaesthetized horses, pronounced ventilation/perfusion mismatching often occurs. Several authors have investigated the effect of lower inspired oxygen fractions (FiO(2)) to reduce formation of absorption atelectasis. This systematic review compared the effects of low (\textless0.6) and high (\textgreater0.8) FiO(2) on the arterial oxygen tension (PaO(2)), the alveolar-to-arterial oxygen tension difference (P(A-a)O(2)), and the PaO(2)/FiO(2) ratio in horses during inhalation anaesthesia. Using the Systematic Review Protocol for Animal Intervention Studies, four experimental and one clinical investigations were deemed suitable for inclusion. A meta-analysis was performed on the four experimental studies. The PaO(2) was significantly lower (p = 0.0007, mean difference -23.54 kPa, 95% CI -37.18, -9.90) with a lower FiO(2). However, the P(A-a)O(2) was also significantly lower (p \textless 0.00001, mean difference -20.80 kPa, 95% CI -26.28, -15.32) when using a low FiO(2). For the PaO(2)/FiO(2) ratio, only one study fitted the inclusion criteria, so no meta-analysis was performed. It is concluded that, while only a limited number of studies are available, the use of a higher FiO(2) in horses during inhalation anaesthesia will result in higher levels of PaO(2), but also a larger P(A-a)O(2) difference. Further studies are needed to increase the level of evidence on this subject.
Savvas, I., Pavlidou, K., Braun, C., Schauvliege, S., Staffieri, F., & Moens, Y. (2021). Evaluation of the Effect of the Inspired Oxygen Fraction on Blood Oxygenation during Inhalant Anaesthesia in Horses: A Systematic Review with Meta-Analysis. Animals (Basel), 11(8). https://doi.org/10.3390/ani11082245 horses, anaesthesia, blood oxygenation