Fructose feeding and hyperuricemia: a systematic review and meta-analysis

Sayehmiri, K. and Ahmadi, I. and Anvari, E.

Clinical Nutrition Research (2020) 9: 122–133

DOI: 10.7762/cnr.2020.9.2.122

Abstract

High fructose feeding has been suggested to involve in several features of metabolic syndrome including hyperuricemia HP. We designed and implemented a study to determine the effect size of fructose intake and the relative risk of HP based on the type of fructose feeding diet or solution, duration of treatment 2-6, 7-10, and \textgreater 10 weeks, and animal race. The required information was accepted from international databases, including PubMed/MEDLINE, Science Direct, Scopus, and etc., from 2009 until 2019 on the basis of predetermined eligibility criteria. The data selection and extraction and quality assessment were performed independently by two researchers. Results were pooled as random effects weighting and reported as standardized mean differences with 95% confidence intervals. Thirty-five studies including 244 rats with fructose consumption were included in the final analysis. The heterogeneity rate of parameters was high I2 = 81.3%, p \textless 0.001 and estimated based on; (1) type of fructose feeding diet; I2 = 79.3%, solution 10%; I2 = 83.4%, solution 20%; I2 = 81.3%, (2) duration of treatment 2-6 weeks; I2 = 86.8%, 7-10 weeks; I2 = 76.3%, and \textgreater 10 weeks; I2 = 82.8%, (3) the animal race Wistar; I2 = 78.6%, Sprague-Dawley; I2 = 83.9%. Overall, the pooled estimate for the all parameters was significant p \textless 0.001. The results of this study indicated that a significant relationship between HP and fructose intake regardless of the treatment duration, animal race, fructose concentration and route of consumption.

Citation

Sayehmiri, K., Ahmadi, I., & Anvari, E. (2020). Fructose feeding and hyperuricemia: a systematic review and meta-analysis. Clinical Nutrition Research, 9(2), 122–133. https://doi.org/10.7762/cnr.2020.9.2.122 meta-analysis, animal models, man, systematic reviews, data analysis, research, studies, feeding, models, human diseases, risk factors, databases, assessment, metabolic disorders, metabolic syndrome, data banks, Non-communicable Human Diseases and Injuries [VV600], Animal Models of Human Diseases [VV400], fructose, rats, quality assurance, quality controls, fruit sugar, hyperuricaemia, hyperuricemia, ketohexose, laevulose, levulose, metabolic diseases, syndromes

Keywords

• meta-analysis
• animal models
• man
• systematic reviews
• data analysis
• research
• studies
• feeding
• models
• human diseases
• risk factors
• databases
• assessment
• metabolic disorders
• metabolic syndrome
• data banks
• Non-communicable Human Diseases and Injuries [VV600]
• Animal Models of Human Diseases [VV400]
• fructose
• rats
• quality assurance
• quality controls
• fruit sugar
• hyperuricaemia
• hyperuricemia
• ketohexose
• laevulose
• levulose
• metabolic diseases
• syndromes