VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Regen Med (2020) 15: 2379–2395
Aim: To ascertain clinical effectiveness of anorganic bovine-derived hydroxyapatite matrix/cell-binding peptide (ABM/P-15) for regeneration of periodontal defects. Materials & methods: Electronic databases (National Library of Medicine [Medline by PubMed], Cochrane Library [Wiley], CINAHL [EBSCO] and Medline [EBSCO]) were systematically searched up to December 2019. Randomized controlled clinical trials comparing ABM/P-15 grafts to conventional surgery for intrabony and gingival recession defects were included and evaluated intrabony defects including clinical attachment level (CAL), probing depth and gingival recession. Results: A significant gain in CAL (1.37 mm), and reduction in probing depth (1.22 mm) were shown by ABM/P-15 grafts than open flap debridement (p \textless 0.00001). The subgroup analysis also showed better results for ABM/P-15 grafts in CAL gain for intrabony defects. For furcation and gingival recession defects, no significant difference was seen. Conclusion: The adjunct use of ABM/P-15 grafts in conventional periodontal surgery is useful for periodontal regeneration of intrabony defects.
Shaikh, M. S., Husain, S., Lone, M. A., Lone, M. A., Akhlaq, H., & Zafar, M. S. (2020). Clinical effectiveness of anorganic bovine-derived hydroxyapatite matrix/cell-binding peptide grafts for regeneration of periodontal defects: a systematic review and meta-analysis. Regen Med, 15(12), 2379–2395. https://doi.org/10.2217/rme-2020-0113 *systematic review, *meta-analysis, *alveolar bone, *bone grafts, *furcation defects, *gingival recession defects, *intrabony defects, *periodontal defects, *periodontal regeneration, *periodontal surgery