VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Veterinary Anaesthesia and Analgesia (2014) 41: 1–13
DOI: 10.1111/vaa.12083
OBJECTIVE: The purpose of this systematic review is to summarize the results of studies which have determined the minimum alveolar concentration (MAC) of isoflurane and sevoflurane in domestic cats. STUDY DESIGN: Systematic review. ANIMALS: Cats. METHODS USED: A comprehensive search of research literature was performed without language restriction. The search utilized the Pubmed, Google Scholar, and CAB Abstracts electronic databases using a combination of free text terms ’Minimum alveolar concentration’, ’sevoflurane’, ’isoflurane’, ’anesthetic’, ’cat’, ’cats’ or ’feline’. The search was conducted from November 2010 to June 2012. RESULTS: The MAC for isoflurane ranged from 1.20 +/- 0.13% to 2.22 +/- 0.35% and the MAC for sevoflurane ranged from 2.5 +/- 0.2% to 3.95 +/- 0.33%. The average MAC for isoflurane was 1.71 +/- 0.07% and for sevoflurane was 3.08 +/- 0.4%. CONCLUSIONS & CLINICAL RELEVANCE: The average MAC for isoflurane was 1.71 +/- 0.07% and for sevoflurane was 3.08 +/- 0.4%. Methodology differed among studies, and particular attention should be paid in the future to appropriate reporting of methods to allow sound conclusions to be made from the results.
Shaughnessy, M. R., & Hofmeister, E. H. (2014). A systematic review of sevoflurane and isoflurane minimum alveolar concentration in domestic cats. Veterinary Anaesthesia and Analgesia, 41(1), 1–13. https://doi.org/10.1111/vaa.12083 Animals, Cats, Anaesthesia, Anaesthetics, Anesthetics, Inhalation, Inhalation/pharmacokinetics, Isoflurane, Isoflurane/pharmacokinetics, Methyl Ethers, Methyl Ethers/pharmacokinetics, Pulmonary Alveoli, sevoflurane