VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Parasitology (2020) 147: 1392–1407
DOI: 10.1017/S0031182020001304
This systematic review investigated the evidence for the therapeutic potential of essential oils (EOs) against Leishmania amazonensis. We searched available scientific publications from 2005 to 2019 in the PubMed and Web of Science electronic databases, according to PRISMA statement. The search strategy utilized descriptors and free terms. The EOs effect of 35 species of plants identified in this systematic review study, 45.7% had half of the maximal inhibitory concentration (IC_\textrm50) 10 \textless IC_\textrm50 50 g mL^\textrm-1 and 14.3% had a 10 \textless IC_\textrm50 g mL^\textrm-1 for promastigote forms of L. amazonensis. EOs from Cymbopogon citratus species had the lowest IC_\textrm50 (1.7 g mL^\textrm-1). Among the plant species analyzed for activity against intracellular amastigote forms of L. amazonensis, 39.4% had an IC_\textrm50 10 \textless IC_\textrm50 50 g mL^\textrm-1, and 33.3% had an IC_\textrm50 10 \textless IC_\textrm50 g mL^\textrm-1. Aloysia gratissima EO showed the lowest IC_\textrm50 (0.16 g mL^\textrm-1) for intracellular amastigotes. EOs of Chenopodium ambrosioides, Copaifera martii and Carapa guianensis, administered by the oral route, were effective in reducing parasitic load and lesion volume in L. amazonensis-infected BALB/c mice. EOs of Bixa orellana and C. ambrosioides were effective when administered intraperitoneally. Most of the studies analyzed in vitro and in vivo for the risk of bias showed moderate methodological quality. These results indicate a stimulus for the development of new phytotherapy drugs for leishmaniasis treatment.
Silva, C. E. de L. da, Oyama, J., Ferreira, F. B. P., Lalucci-Silva, M. P. de P., Lordani, T. V. A., Silva, R. C. de L. da, Monich, M. de S. T., Teixeira, J. J. V., & Lonardoni, M. V. C. (2020). Effect of essential oils on Leishmania amazonensis: a systematic review. Parasitology, 147(13), 1392–1407. https://doi.org/10.1017/S0031182020001304 animal models, in vivo, man, systematic reviews, plants, essential oils, in vitro, human diseases, infections, parasites, parasitoses, protozoal infections, laboratory animals, amastigotes, diffuse cutaneous leishmaniasis, essential oil plants, leishmaniasis, medicinal plants, oil plants, Microbiology (General) [ZZ390], Protozoa, protozoal diseases, Animal Models of Human Diseases [VV400], parasitic diseases, parasitic infestations, parasitosis, Protozoan, Helminth and Arthropod Parasites of Humans [VV220], drug plants, medicinal herbs, officinal plants, Non-food/Non-feed Plant Products [SS200], Leishmania, leishmaniosis, Leishmania amazonensis, mice, Aloysia gratissima, Bixa orellana, Carapa guianensis, Copaifera, Copaifera martii, Cymbopogon citratus, Dysphania ambrosioides, essential oil crops, oil crops