Effects of Quercetin on Cardiac Function in Pressure Overload and Postischemic Cardiac Injury in Rodents: a Systematic Review and Meta-Analysis

Siti, H.M. and Jalil, J. and Asmadi, A.Y. and Kamisah, Y.

Cardiovascular drugs and therapy (2022) 36: 15–29

DOI: 10.1007/s10557-020-07100-y

Abstract

PURPOSE: Cardiac dysfunction can occur as a sequela of a state of prolonged pressure overload and postischemic injury. Flavonoids such as quercetin may be protective against cardiovascular disease. This study aimed to systematically assess the effects of quercetin on cardiac function in pressure overload and postischemia-reperfusion injury in rodents. METHODS: A systematic search of the literature up to May 2020 was conducted in PubMed, Ovid Medline, EBSCOhost, Scopus, and the Cochrane Library to identify relevant published studies on quercetin and cardiac function using standardized criteria. Meta-analyses were performed on animal studies of pressure overload and ischemia-reperfusion (I/R) injury. RESULTS: The effects of quercetin on cardiac function in both models were qualitatively reported in 14 studies. The effects of quercetin in four pressure-overload model studies involving 73 rodents and eight I/R-injury model studies involving 120 rodents were quantitatively assessed by meta-analysis. Quercetin improved the overall cardiac function in both pressure overload (n = 4 studies, n = 73 rodents; SMD = - 1.50; 95% CI: - 2.66 to - 0.33; P \textless 0.05; I(2) = 74.05%) and I/R injury (n = 8 studies, n = 120 rodents; SMD = - 1.81; 95% CI: - 3.05 to - 0.56; P \textless 0.01; I(2) = 84.93%) models. The improvement was associated with amelioration in cardiac structure in the pressure-overload model and both systolic and diastolic functioning in the I/R-injury model. CONCLUSION: The present meta-analysis suggested that quercetin has beneficial effects for improving cardiac left ventricular dysfunction in both pressure-overload and I/R-injury models.

Citation

Siti, H. M., Jalil, J., Asmadi, A. Y., & Kamisah, Y. (2022). Effects of Quercetin on Cardiac Function in Pressure Overload and Postischemic Cardiac Injury in Rodents: a Systematic Review and Meta-Analysis. Cardiovascular Drugs and Therapy, 36(1), 15–29. https://doi.org/10.1007/s10557-020-07100-y Animals, Disease Models, Animal, Rats, Mice, Rodentia, Quercetin/*pharmacology, Cardiac function, Flavonoid, Left ventricular end-diastolic pressure, Postischemia-reperfusion injury, Pressure overload, Quercetin, Cardiotonic Agents/pharmacology, Myocardial Reperfusion Injury/*drug therapy/physiopathology, Ventricular Dysfunction, Left/*drug therapy/physiopathology, Ventricular Pressure/drug effects

Keywords

• Animals
• Disease Models
• Animal
• Rats
• Mice
• Rodentia
• Quercetin/*pharmacology
• Cardiac function
• Flavonoid
• Left ventricular end-diastolic pressure
• Postischemia-reperfusion injury
• Pressure overload
• Quercetin
• Cardiotonic Agents/pharmacology
• Myocardial Reperfusion Injury/*drug therapy/physiopathology
• Ventricular Dysfunction
• Left/*drug therapy/physiopathology
• Ventricular Pressure/drug effects