VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
PLoS Neglected Tropical Diseases (2022) 16:
DOI: 10.1371/journal.pntd.0010546
T cells recognize their ligand, the peptide major histocompatibility complex (MHC), via the T-cell receptor (TCR), which is composed of covalently linked a and beta or P and chains. This recognition is critical for T-cell ontogeny and controls the selection, activation, and function of T lymphocytes. Specific TCR abeta variable regions have been associated with immunopathogenesis of Chagas disease. Here, we present a systematic review that compiles experimental in vivo and human data regarding the preferential expression of variable alpha (Va) and variable beta (Vbeta) chain regions in Trypanosoma cruzi infection. The original studies indexed in PubMed/Medline, Scopus, and Web of Science databases were screened according to the PRISMA strategy. The analysis showed that expression of TCR Va subfamilies were evaluated in one human study, and, unlike TCR Vbeta, TCR Va presented a more restricted usage. Despite the great variability in the usage of TCR Vbeta regions in human Chagas disease, a down-regulation of TCR Vbeta5 expression by T cells from patients in the acute phase of the disease was shown. Opposingly, this TCR region was found overly expressed in CD4+ T cells from chronic Chagas patients. It was also demonstrated that murine Vbeta9+ T cells derived from nonlymphoid organs of T. cruzi-infected animals had a modulatory profile, while splenic Vbeta9+ T cells produced inflammatory cytokines, indicating that although they display the same TCR Vbeta region usage, these cells are functionally distinct. Despite the limitations of few papers and year of publication of the studies, compiling the data derived from them reveals that further investigation of TCR usage will point to their potential role in protective or pathogenic responses, as biomarkers of disease progression, and in the search for dominant peptides potentially useful for the development of vaccines or therapies.
Souza-Silva, T. G. de, Gollob, K. J., & Dutra, W. O. (2022). T-cell receptor variable region usage in Chagas disease: a systematic review of experimental and human studies. PLoS Neglected Tropical Diseases, 16(9). https://doi.org/10.1371/journal.pntd.0010546 Humans, cytokines, animal models, systematic reviews, literature reviews, human diseases, infections, parasites, parasitoses, protozoal infections, laboratory animals, genes, T lymphocytes, disease models, gene expression, trypanosomiasis, Chagas’ disease, biological markers, CD4+ lymphocytes, Chagas Disease, Humanism, Humanities, Receptors, Antigen, T-Cell, recombination