VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Preventive Veterinary Medicine (1995) 25: 7–17
DOI: 10.1016/0167-5877(95)00493-9
72 trials were identified in 27 studies recorded on VETCD, CAB and MEDLINE databases. Data concerning animals, vaccination procedure, experimental methodology, vaccine type and raw mean lung-lesion scores were registered from each publication. Vaccine types were grouped into 11 or 10 categories based on the subunit content in each preparation for the first and second analysis, respectively. The least-squares means of the postchallenge lung-lesion scores of each vaccine type were then compared after controlling for all the other variables in an analysis of variance using Fischer’s protected least significant difference. The statistical analysis was done using a general linear models procedure. Protective indices for each vaccine type were calculated as a function of independent probabilities of protection among vaccinates and controls, and were then compared in a similar model. Cattle vaccinated with live vaccines had the smallest lung-lesion scores (9+or-8) which significantly differed from that of controls (44+or-8), bacterins (23+or-6) and live streptomycin dependent (Sm[super:D], 38+or-12) or modified live (31+or-10). KSCN extract (9+or-10), bacterin, and culture supernatant (CS, 20+or-9) also had significantly lower lung-lesion scores compared to controls. The CS and KSCN vaccines showed a significantly better protective index (PI, 0.70 and 0.68, respectively) than bacterins (0.50) or bacterin + CS (0.44) vaccines. Saline extract and live vaccines had better PI (0.60 and 0.70, respectively) compared to bacterins.
Srinand, S., Ames, T. R., Maheswaran, S. K., & King, V. L. (1995). Efficacy of various vaccines against pneumonic pasteurellosis in cattle: a meta-analysis. Preventive Veterinary Medicine, 25(1), 7–17. https://doi.org/10.1016/0167-5877(95)00493-9 [Indexed using CAB Thesaurus terms], animals, Artiodactyla, Chordata, eukaryotes, mammals, ungulates, vertebrates, Bos, Bovidae, cattle, Host Resistance and Immunity [HH600], ruminants, vaccines, statistical analysis, statistical methods, research, studies, prokaryotes, bacteria, immunization, bacterial diseases, Parasites, efficacy, experimental infections, adjuvants, lung diseases, respiratory diseases, attenuated vaccines, bacterial infections, bacterioses, Gracilicutes, immune sensitization, inactivated vaccines, killed vaccines, live vaccines, Pasteurella, Pasteurella haemolytica, Pasteurellaceae, pasteurellosis, Pathogens and Biogenic Diseases of Animals [LL820], pneumonia, Vectors