Antiplasmodial, antimalarial activities and toxicity of African medicinal plants: a systematic review of literature

Tajbakhsh, E. and Kwenti, T. E. and Kheyri, P. and Nezaratizade, S. and Lindsay, D. S. and Khamesipour, F.

Malaria Journal (2021) 20:

DOI: 10.1186/s12936-021-03866-0

Abstract

Background: Malaria still constitutes a major public health menace, especially in tropical and subtropical countries. Close to half a million people mainly children in Africa, die every year from the disease. With the rising resistance to frontline drugs (artemisinin-based combinations), there is a need to accelerate the discovery and development of newer anti-malarial drugs. A systematic review was conducted to identify the African medicinal plants with significant antiplasmodial and/or anti-malarial activity, toxicity, as wells as assessing the variation in their activity between study designs (in vitro and in vivo).

Citation

Tajbakhsh, E., Kwenti, T. E., Kheyri, P., Nezaratizade, S., Lindsay, D. S., & Khamesipour, F. (2021). Antiplasmodial, antimalarial activities and toxicity of African medicinal plants: a systematic review of literature. Malaria Journal, 20(349). https://doi.org/10.1186/s12936-021-03866-0 man, systematic reviews, literature reviews, Fabaceae, plants, in vitro, Africa, children, Information and Documentation [CC300], safety, toxicity, medicinal plants, leaves, plant extracts, databases, data banks, clinical trials, traditional medicines, Animal and in vitro Models for Pharmaceuticals [VV450], Animal Models of Human Diseases [VV400], Pesticides and Drugs, Protozoan, Helminth and Arthropod Parasites of Humans [VV220], drug plants, medicinal herbs, officinal plants, Control [HH405], Non-food/Non-feed Plant Products [SS200], Pharmacology [VV730], Alchornea cordifolia, Annonaceae, anti-malarial properties, anti-protozoal properties, antimalarial properties, antiprotozoal properties, Apocynaceae, Azadirachta indica, Cochlospermum, Cochlospermum planchonii, Cryptolepis sanguinolenta, drug development, Euphorbiaceae, Flueggea, Flueggea virosa, Lamiaceae, Maytenus senegalensis, Meliaceae, Nauclea latifolia, neem, Nigeria, Picralima nitida, Rubiaceae, Rutaceae, subsaharan Africa, Vernonia amygdalina, Zanthoxylum, Zanthoxylum chalybeum

Keywords

• man
• systematic reviews
• literature reviews
• Fabaceae
• plants
• in vitro
• Africa
• children
• Information and Documentation [CC300]
• safety
• toxicity
• medicinal plants
• leaves
• plant extracts
• databases
• data banks
• clinical trials
• traditional medicines
• Animal and in vitro Models for Pharmaceuticals [VV450]
• Animal Models of Human Diseases [VV400]
• Pesticides and Drugs
• Protozoan
• Helminth and Arthropod Parasites of Humans [VV220]
• drug plants
• medicinal herbs
• officinal plants
• Control [HH405]
• Non-food/Non-feed Plant Products [SS200]
• Pharmacology [VV730]
• Alchornea cordifolia
• Annonaceae
• anti-malarial properties
• anti-protozoal properties
• antimalarial properties
• antiprotozoal properties
• Apocynaceae
• Azadirachta indica
• Cochlospermum
• Cochlospermum planchonii
• Cryptolepis sanguinolenta
• drug development
• Euphorbiaceae
• Flueggea
• Flueggea virosa
• Lamiaceae
• Maytenus senegalensis
• Meliaceae
• Nauclea latifolia
• neem
• Nigeria
• Picralima nitida
• Rubiaceae
• Rutaceae
• subsaharan Africa
• Vernonia amygdalina
• Zanthoxylum
• Zanthoxylum chalybeum