Systematic Review on Characteristics and Reporting Quality of Animal Studies in Liver Regeneration Triggered by Portal Vein Occlusion and Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy: Adherence to the ARRIVE Guidelines

Tihanyi, D. K. and Szijarto, A. and Fülöp, A. and Denecke, B. and Lurje, G. and Neumann, U. P. and Czigany, Z. and Tolba, R.

J Surg Res (2019) 235: 578–590

DOI: 10.1016/j.jss.2018.10.038

Abstract

BACKGROUND: Portal vein occlusion and associating liver partition and portal vein ligation for staged hepatectomy techniques are in the spotlight of oncological liver surgery. Research involving animal models is indispensable to study the mechanisms of liver regeneration. Inaccurate reporting acts as a significant barrier during the correct interpretation of preclinical findings. Hence, we performed a systematic review to evaluate the status quo of the reporting standards and to assess the potential factors influencing reporting in animal studies, which are focusing on portal vein occlusion and/or associating liver partition and portal vein ligation for staged hepatectomy techniques. MATERIALS AND METHODS: A systematic review was performed in the PubMed and Ovid MEDLINE databases. Baseline study characteristics were recorded, and quality assessment was performed using the Animals in Research: Reporting in vivo Experiments (ARRIVE) checklist. RESULTS: A total of 107 research articles were included for the comprehensive assessment. In the subgroup analysis, newer reports and studies from the post-ARRIVE era, and reports from Europe were all associated with significantly higher ARRIVE scores (P \textless 0.05). Univariable regression analysis confirmed these factors as predictors of higher reporting quality. However, in the multivariable analysis, only publishing in the post-ARRIVE era has been found as single independent predictor of higher reporting standards (P = 0.028 post-ARRIVE total score 75th percentile; P = 0.000 post-ARRIVE total score median). CONCLUSIONS: Although an improving trend has been observed in reporting quality over the past years, this effect was clearly insufficient. Our results emphasize the need for further measures to improve the methodical quality at all levels of planning, execution, and reporting of preclinical studies in liver regeneration research.

Citation

Tihanyi, D. K., Szijarto, A., Fülöp, A., Denecke, B., Lurje, G., Neumann, U. P., Czigany, Z., & Tolba, R. (2019). Systematic Review on Characteristics and Reporting Quality of Animal Studies in Liver Regeneration Triggered by Portal Vein Occlusion and Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy: Adherence to the ARRIVE Guidelines. J Surg Res, 235, 578–590. https://doi.org/10.1016/j.jss.2018.10.038 Animals, *Liver Regeneration, Ligation, *Hepatectomy, Animal Experimentation, *ARRIVE guidelines, Research Report/*standards, *alpps, *Liver tumors, *Portal vein occlusion, *Reporting quality, Portal Vein

Keywords

• Animals
• *Liver Regeneration
• Ligation
• *Hepatectomy
• Animal Experimentation
• *ARRIVE guidelines
• Research Report/*standards
• *alpps
• *Liver tumors
• *Portal vein occlusion
• *Reporting quality
• Portal Vein