A meta-analysis on experimental infections with porcine circovirus type 2 (PCV2)

Tomas, A and Fernandes, L T and Valero, O and Segales, J

Veterinary Microbiology (2008) 132: 260–273

DOI: 10.1016/j.vetmic.2008.05.023

Abstract

A meta-analysis was performed with the aim to identify factors with a relevant influence on the expression of clinical postweaning multisystemic wasting syndrome (PMWS) under experimental conditions. Data from 44 studies were included in the analysis. Several variables were studied: number of pigs in the experiment, intake of colostrum, serological status against porcine circovirus type 2 (PCV2), strain of PCV2 used for inoculation, the route and dose of inoculation, and use of potential triggering factors (such as co-infections, vaccinations, or immunomodulator products). Multiple correspondence analysis and log-linear regression methods were used to establish the relationships between the studied variables and the number of PCV2 infected pigs that developed PMWS. Based on the results of the meta-analysis, the most successful animal experiment aimed to develop PMWS should include: (1) colostrum-deprived pigs, (2) age of inoculation below 3 weeks, (3) high doses of PCV2 inoculum, (4) PCV2 strain from genotype 1, and (5) co-infection with another swine pathogen as a triggering factor.

Citation

Tomas, A., Fernandes, L. T., Valero, O., & Segales, J. (2008). A meta-analysis on experimental infections with porcine circovirus type 2 (PCV2). Veterinary Microbiology, 132(3-4), 260–273. https://doi.org/10.1016/j.vetmic.2008.05.023 Animals, Swine, Pigs, Circoviridae Infections/veterinary, Circovirus/classification, Porcine Postweaning Multisystemic Wasting Syndrome/virology

Keywords

• Animals
• Swine
• Pigs
• Circoviridae Infections/veterinary
• Circovirus/classification
• Porcine Postweaning Multisystemic Wasting Syndrome/virology