VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Epidemiology and Infection (2011) 139: 1127–1144
DOI: 10.1017/s0950268811000677
The objectives of our study were to identify and categorize primary research investigating swine/pork as a source of zoonotic hepatitis E virus (HEV) using the relatively new technique of scoping study, and to investigate the potential association between human exposure to swine/pork and HEV infection quantitatively using systematic review/meta-analysis methodology. From 1890 initially identified abstracts, 327 were considered for the review. Five study design types (cross-sectional, prevalence, genotyping, case-report and experimental transmission studies) were identified. A significant association between occupational exposure to swine and human HEV IgG seropositivity was reported in 10/13 cross-sectional studies. The association reported between pork consumption and HEV IgG seropositivity was inconsistent. The quantification of viral load in swine and retail pork, viral load required for infection in primates, cohort and case-control studies in humans, and formal risk assessment are recommended before specific public-health policy actions are taken.
Wilhelm, B. J., Rajic, A., Greig, J., Waddell, L., Trottier, G., Houde, A., Harris, J., Borden, L. N., & Price, C. (2011). A systematic review/meta-analysis of primary research investigating swine, pork or pork products as a source of zoonotic hepatitis E virus. Epidemiology and Infection, 139(8), 1127–1144. https://doi.org/10.1017/s0950268811000677 Animals, Humans, Swine, Pigs, Occupational Exposure, Biomedical Research/statistics & numerical data/trends, Hepatitis E virus/isolation & purification, Hepatitis E/epidemiology/transmission/veterinary/virology, Meat/virology, Swine Diseases/epidemiology/transmission/virology, Viral Load, Zoonoses/epidemiology/transmission/virology