Comparative efficacy of teat sealants given prepartum for prevention of intramammary infections and clinical mastitis: a systematic review and network meta-analysis

Winder, C. B. and Sargeant, J. M. and Hu, D. and Wang, C. and Kelton, D. F. and Leblanc, S. J. and Duffield, T. F. and Glanville, J. and Wood, H. and Churchill, K. J. and Dunn, J. and Bergevin, M. D. and Dawkins, K. and Meadows, S. and Deb, B. and Reist, M. and Moody, C. and O’Connor, A. M.

Anim Health Res Rev (2019) 20: 182–198

DOI: 10.1017/s1466252319000276

Abstract

A systematic review and network meta-analysis were conducted to assess the relative efficacy of internal or external teat sealants given at dry-off in dairy cattle. Controlled trials were eligible if they assessed the use of internal or external teat sealants, with or without concurrent antimicrobial therapy, compared to no treatment or an alternative treatment, and measured one or more of the following outcomes: incidence of intramammary infection (IMI) at calving, IMI during the first 30 days in milk (DIM), or clinical mastitis during the first 30 DIM. Risk of bias was based on the Cochrane Risk of Bias 2.0 tool with modified signaling questions. From 2280 initially identified records, 32 trials had data extracted for one or more outcomes. Network meta-analysis was conducted for IMI at calving. Use of an internal teat sealant (bismuth subnitrate) significantly reduced the risk of new IMI at calving compared to non-treated controls (RR = 0.36, 95% CI 0.25-0.72). For comparisons between antimicrobial and teat sealant groups, concerns regarding precision were seen. Synthesis of the primary research identified important challenges related to the comparability of outcomes, replication and connection of interventions, and quality of reporting of study conduct.

Citation

Winder, C. B., Sargeant, J. M., Hu, D., Wang, C., Kelton, D. F., Leblanc, S. J., Duffield, T. F., Glanville, J., Wood, H., Churchill, K. J., Dunn, J., Bergevin, M. D., Dawkins, K., Meadows, S., Deb, B., Reist, M., Moody, C., & O’Connor, A. M. (2019). Comparative efficacy of teat sealants given prepartum for prevention of intramammary infections and clinical mastitis: a systematic review and network meta-analysis. Anim Health Res Rev, 20(2), 182–198. https://doi.org/10.1017/s1466252319000276 Animals, Female, Cattle, Anti-Bacterial Agents/therapeutic use, Bismuth/*pharmacology, Mammary Glands, Animal, Network Meta-Analysis, *dairy cattle, *dry cow, *dry-off, *mixed treatment comparison, Antacids/pharmacology, Mastitis, Bovine/*prevention & control

Keywords

• Animals
• Female
• Cattle
• Anti-Bacterial Agents/therapeutic use
• Bismuth/*pharmacology
• Mammary Glands
• Animal
• Network Meta-Analysis
• *dairy cattle
• *dry cow
• *dry-off
• *mixed treatment comparison
• Antacids/pharmacology
• Mastitis
• Bovine/*prevention & control