Perinatal protein undernutrition and cardiovascular system: a systematic review

Xavier, J. E. and Antonio, E. A. and Oliveira, L. dos S. and Souza, S. L. de and Medeiros, J. P. de and Lima, L. C. and Fraga, C. A. de C. and Miguel, R. D. da S.

Journal of Morphological Sciences (2018) 35: 203–206

DOI: 10.1055/s-0038-1675361

Abstract

The present study is a systematic review of the literature that aimed to characterize the profile in animal models used to study perinatal protein malnutrition correlating with the cardiovascular system and the implications of malnutrition to the heart. Therefore, an extensive search was conducted in the PubMed, BVS, and SciELO databases, using combinations of the descriptors protein malnutrition, pregnancy, heart, lactation, and cardiovascular system. A total of 247 articles were found, but after excluding duplicities and applying the inclusion/exclusion criteria, only 12 papers remained. The analysis of the results shows that the diet used in the studies has a protein content of between 17 and 22% for the control animals, and of between 0 and 9% for the animals submitted to perinatal protein malnutrition. The main morphofunctional changes observed in the cardiovascular system are related to high blood pressure, increased apoptosis of cardiomyocytes, and reduction in the absolute size of the heart, among other ultrastructural and molecular changes.

Citation

Xavier, J. E., Antonio, E. A., Oliveira, L. dos S., Souza, S. L. de, Medeiros, J. P. de, Lima, L. C., Fraga, C. A. de C., & Miguel, R. D. da S. (2018). Perinatal protein undernutrition and cardiovascular system: a systematic review. Journal of Morphological Sciences, 35(4), 203–206. https://doi.org/10.1055/s-0038-1675361 pregnancy, apoptosis, animals, gestation, reviews, animal models, man, systematic reviews, lactation, research, studies, literature reviews, composition, models, human diseases, analysis, Information and Documentation [CC300], databases, data banks, blood pressure, cardiovascular system, circulatory system, necrosis, Human Health and Biology (General) [VV000], high blood pressure, hypertension, Animal Models of Human Diseases [VV400], Animal Models of Human Nutrition [VV140], cardiovascular diseases, malnutrition, heart, protein content, Human Reproduction and Development [VV060], protein deficiencies, protein malnutrition, undernutrition

Keywords

• pregnancy
• apoptosis
• animals
• gestation
• reviews
• animal models
• man
• systematic reviews
• lactation
• research
• studies
• literature reviews
• composition
• models
• human diseases
• analysis
• Information and Documentation [CC300]
• databases
• data banks
• blood pressure
• cardiovascular system
• circulatory system
• necrosis
• Human Health and Biology (General) [VV000]
• high blood pressure
• hypertension
• Animal Models of Human Diseases [VV400]
• Animal Models of Human Nutrition [VV140]
• cardiovascular diseases
• malnutrition
• heart
• protein content
• Human Reproduction and Development [VV060]
• protein deficiencies
• protein malnutrition
• undernutrition