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Meat and fish intake and type 2 diabetes: Dose-response meta-analysis of prospective cohort studies

Yang, X. and Li, Y. and Wang, C. and Mao, Z. and Zhou, W. and Zhang, L. and Fan, M. and Cui, S. and Li, L.

Diabetes Metab (2020) 46: 345–352

DOI: 10.1016/j.diabet.2020.03.004

Abstract

AIMS: This meta-analysis aimed to quantitatively examine the possible associations between total meat, red meat, processed meat, poultry and fish intakes and type 2 diabetes (T2D). METHODS: Relevant articles were identified in PubMed, Embase and Web of Science databases using a search time up to January 2019. Generalized least-squares trend estimations and restricted cubic spline regression models were used for analysis. RESULTS: Twenty-eight articles were included in the analysis. When comparing the highest with the lowest category of meat intake, the summary relative risk of T2D was 1.33 (95% CI: 1.16-1.52) for total meat, 1.22 (95% CI: 1.16-1.28) for red meat, 1.25 (95% CI: 1.13-1.37) for processed meat, 1.00 (95% CI: 0.93-1.07) for poultry and 1.01 (95% CI: 0.93-1.10) for fish. In the dose-response analysis, each additional 100g/day of total and red meat, and 50g/day of processed meat, were found to be associated with a 36% (95% CI: 1.23-1.49), 31% (95% CI: 1.19-1.45) and 46% (95% CI: 1.26-1.69) increased risk of T2D, respectively. In addition, there was evidence of a non-linear dose-response association between processed meat and T2D (P=0.004), with the risk increasing by 30% with increasing intakes up to 30g/day. CONCLUSION: Our meta-analysis has shown a linear dose-response relationship between total meat, red meat and processed meat intakes and T2D risk. In addition, a non-linear relationship of intake of processed meat with risk of T2D was detected.

Citation

Yang, X., Li, Y., Wang, C., Mao, Z., Zhou, W., Zhang, L., Fan, M., Cui, S., & Li, L. (2020). Meat and fish intake and type 2 diabetes: Dose-response meta-analysis of prospective cohort studies. Diabetes Metab, 46(5), 345–352. https://doi.org/10.1016/j.diabet.2020.03.004 *Meta-analysis, *Type 2 diabetes, *Fish, *Meat, *Prospective

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