VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Pulm Pharmacol Ther (2019) 54: 39–52
DOI: 10.1016/j.pupt.2018.11.007
BACKGROUND: Over the years, mesenchymal stromal (stem) cells (MSCs) have been pre-clinically applied in the treatment of variety kinds of diseases including asthma and chronic lung diseases. Aim of the current study was to systematically review and to conduct meta-analysis on the published studies of MSC treatment in asthma animal models. METHODS: Publications on the MSC and asthma treatment was thoroughly searched in the electronic databases. Statistical analysis was then performed using the Comprehensive Meta-Analysis software (Version 3). Effect of MSC therapy on asthma model was assessed by Hedges’s g with 95% confidence intervals (95% CIs). Random effect model was used due to the heterogeneity between the studies. RESULTS: Meta-analysis of the 32 included studies showed that MSC transplantation was significantly in favor of attenuating lung injury and remodeling (Hedges’s g = -9.104 ± 0.951 with 95% CI: -10.969 ∼ -7.240, P \textless 0.001) and airway inflammation (Hedges’s g = -4.146 ± 0.688 with 95% CI: -5.495 ∼ -2.797, P \textless 0.001). The mechanism of MSC therapy in asthma seems to be regulating the balance of Th1 cytokine and Th2 cytokines (IFN-γ: Hedges’s g = 4.779 ± 1.408 with 95% CI: 1.099-2.725, P \textless 0.001; IL-4: Hedges’s g = -10.781 ± 1.062 with 95% CI: -12.863 ∼ -8.699, P \textless 0.001; IL-5: Hedges’s g = -10.537 ± 1.269 with 95% CI: -13.025 ∼ -8.050, P \textless 0.001; IL-13: Hedges’s g = -6.773 ± 0.788 with 95% CI: -8.318 ∼ -5.229, P \textless 0.001). CONCLUSION: Findings of the current systemic review suggested a potential role for MSCs in asthma treatment although it is still challenging in clinical practice. The mechanisms of MSCs in pre-clinical asthma treatment may be associated with attenuating airway inflammation through regulating Th1 and Th2 cytokines.
Zhang, L. B., & He, M. (2019). Effect of mesenchymal stromal (stem) cell (MSC) transplantation in asthmatic animal models: A systematic review and meta-analysis. Pulm Pharmacol Ther, 54, 39–52. https://doi.org/10.1016/j.pupt.2018.11.007 Animals, Disease Models, Animal, Humans, Treatment Outcome, Cytokines/*metabolism, Mesenchymal Stem Cell Transplantation/*methods, *Asthma, *Systematic review, *Mesenchymal stromal (stem) cell (MSC), *Meta-Analysis, Asthma/physiopathology/*therapy, Th1 Cells/metabolism, Th2 Cells/metabolism