Efficacy of extracellular vesicles from mesenchymal stem cells on osteoarthritis in animal models: a systematic review and meta-analysis

Zhang, B. and Tian, X. and Qu, Z. and Liu, J. and Yang, L. and Zhang, W.

Nanomedicine (Lond) (2021) 16: 1297–1310

DOI: 10.2217/nnm-2021-0047

Abstract

Background: Some studies have reported results from the use of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) to treat osteoarthritis (OA). Objective: To evaluate the efficacy of MSC-EVs as a treatment for OA. Data sources: Databases were searched using the terms ’mesenchymal stem cells’, ’osteoarthritis’ and ’extracellular vesicles.’ Study eligibility criteria: Studies performed in animal models utilizing MSC-EVs to treat OA that described the macroscopic evaluation or histological evaluation were included. Study appraisal: The quality of the studies was examined using the CAMARADES quality checklist. Results: MSC-EVs were superior to the placebo in the macroscopic evaluation and histological evaluation. MSC-EVs were more effective in the early stage of OA and once a week was better than multiple times a week. Limitations: The included studies were highly heterogeneous. Conclusion: MSC-EVs may improve the results of macroscopic and histological evaluations of OA.

Citation

Zhang, B., Tian, X., Qu, Z., Liu, J., Yang, L., & Zhang, W. (2021). Efficacy of extracellular vesicles from mesenchymal stem cells on osteoarthritis in animal models: a systematic review and meta-analysis. Nanomedicine (Lond), 16(15), 1297–1310. https://doi.org/10.2217/nnm-2021-0047 mesenchymal stem cell, meta-analysis, osteoarthritis, animal model, extracellular vesicles

Keywords

• mesenchymal stem cell
• meta-analysis
• osteoarthritis
• animal model
• extracellular vesicles