Fish Consumption and Stroke Risk: A Meta-Analysis of Prospective Cohort Studies

Zhao, W. and Tang, H. and Yang, X. and Luo, X. and Wang, X. and Shao, C. and He, J.

J Stroke Cerebrovasc Dis (2019) 28: 604–611

DOI: 10.1016/j.jstrokecerebrovasdis.2018.10.036

Abstract

BACKGROUND: Inconsistent results of the association between fish consumption and stroke risk have been indicated in previous epidemiological studies. Therefore, we performed a meta-analysis of prospective cohort studies to estimate the impact of fish consumption on stroke risk. METHODS: The PubMed and EMBASE databases were searched through a computer search. Prospective cohort studies satisfying predetermined inclusion criterion were included. Random-effect model was adopted in this meta-analysis. Analysis of subgroup, sensitivity, publication bias, dose-response, power, and quality of evidence was also conducted. RESULTS: Thirty one publications including 33 independent prospective cohort studies were identified in this meta-analysis. In the primary analysis of the highest versus lowest categories of fish consumption, pooled results indicated that a significant trend toward an inverse association between fish intake and stroke risk (HR = .90, 95% confidence interval [CI] .85-.96). Further subgroup analyses indicated an inverse association was more pronounced in the group of hemorrhagic stroke (HR=.88, 95% CI .80-.96), female (HR =.83, 95% CI .75-.92), and Asia-Pacific (HR = .87, 95% CI .80-.95). Both the funnel plot and Egger tests suggested no evidence of publication bias. Dose-response analysis showed a linear relationship between fish intake and stroke and the risk of stroke decreased by 2%-12% with increasing intake of fish up to 100-700 g/week. According to the NutriGrade scoring system, the level of metaevidence quality was moderate. CONCLUSIONS: Based on current evidence from prospective cohort studies, we concluded that fish consumption was associated with a decreased risk of stroke.

Citation

Zhao, W., Tang, H., Yang, X., Luo, X., Wang, X., Shao, C., & He, J. (2019). Fish Consumption and Stroke Risk: A Meta-Analysis of Prospective Cohort Studies. J Stroke Cerebrovasc Dis, 28(3), 604–611. https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.10.036 Male, Aged, Aged, 80 and over, Female, Humans, Middle Aged, Risk Factors, Prospective Studies, meta-analysis, risk, fish, Recommended Dietary Allowances, *Diet, Healthy, *Risk Reduction Behavior, *Seafood, Nutritive Value, Protective Factors, Stroke, Stroke/diagnosis/epidemiology/*prevention & control

Keywords

• Male
• Aged
• Aged
• 80 and over
• Female
• Humans
• Middle Aged
• Risk Factors
• Prospective Studies
• meta-analysis
• risk
• fish
• Recommended Dietary Allowances
• *Diet
• Healthy
• *Risk Reduction Behavior
• *Seafood
• Nutritive Value
• Protective Factors
• Stroke
• Stroke/diagnosis/epidemiology/*prevention & control