Ligustrazine Exerts Cardioprotection in Animal Models of Myocardial Ischemia/Reperfusion Injury: Preclinical Evidence and Possible Mechanisms

Zheng, Q. and Huang, Y. Y. and Zhu, P. C. and Tong, Q. and Bao, X. Y. and Zhang, Q. H. and Zheng, G. Q. and Wang, Y.

Front Pharmacol (2018) 9: 729

DOI: 10.3389/fphar.2018.00729

Abstract

Ligustrazine (Lig) is one of the main effective components of Ligusticum Chuanxiong Hort, which possesses a variety of biological activities in the cardiovascular system. Here, we conducted a preclinical systematic review to investigate the efficacy of Lig for animal models of myocardial ischemia/reperfusion injury and its possible mechanisms. Twenty-five studies involving 556 animals were identified by searching 6 databases from inception to August 2017. The methodological quality was assessed by using Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADES) 10-item checklist. All the data were analyzed using Rev-Man 5.3 software. As a result, the score of study quality ranged from 2 to 6 points. Meta-analyses showed Lig can significantly decrease the myocardial infarct size, cardiac enzymes and troponin compared with control (P \textless 0.01). The possible mechanisms of Lig for myocardial infarction are antioxidant, anti-inflammatory, anti-apoptosis activities and improving coronary blood flow and myocardial metabolism. In conclusion, the findings indicated that Lig exerts cardio protection through multiple signaling pathways in myocardial ischemia/reperfusion injury.

Citation

Zheng, Q., Huang, Y. Y., Zhu, P. C., Tong, Q., Bao, X. Y., Zhang, Q. H., Zheng, G. Q., & Wang, Y. (2018). Ligustrazine Exerts Cardioprotection in Animal Models of Myocardial Ischemia/Reperfusion Injury: Preclinical Evidence and Possible Mechanisms. Front Pharmacol, 9, 729. https://doi.org/10.3389/fphar.2018.00729 meta-analysis, efficacy, mechanisms, ligustrazine, myocardial ischemia/reperfusion injury

Keywords

• meta-analysis
• efficacy
• mechanisms
• ligustrazine
• myocardial ischemia/reperfusion injury