VetSRev
Database of veterinary systematic reviews
Database of veterinary systematic reviews
Evidence-based Complementary and Alternative Medicine (2021) 2021:
DOI: 10.1155/2021/6016874
Background: Osteoporosis is a major disease that affects the quality of life of middle-aged and old people, so it is very important to find efficient and safe drugs to treat osteoporosis. The purpose of this study was to investigate the therapeutic effect of naringin on postmenopausal osteoporosis in ovariectomized (OVX) rats. Methods: Chinese biomedical databases, CNKI, PubMed, EMBASE, and Wan Fang were searched for articles from inception to March 2020. Two independent researchers screened articles according to inclusion criteria. RevMan 5.3 was used for data analysis. Results: Ten studies were included in the systematic review. The bone mineral density (BMD) significantly increased after naringin treatment (weighted mean difference, 0.06; 95% CI, 0.03-0.09; P \textless 0.01). There was no significant increase in BMD after estrogen treatment compared with naringin (weighted mean difference, 0.00; 95% CI, -0.00 to 0.01; P = 0.06). The trabecular bone volume (BV/TV) (weighted mean difference, 2.09; 95% CI, 1.85-2.34; P \textless 0.01) and trabecular thickness (Tb.Th) (weighted mean difference, 6.65; 95% CI, 6.55-6.74; P \textless 0.01) significantly increased after using naringin. Conclusions: Naringin had been shown to promote bone formation in OVX rats. However, the mechanism of naringin needs more research to confirm.
Zhu Zhu, Xie WenJing, Li YanYan, Zhu ZaiOu, & Zhang Wei. (2021). Effect of naringin treatment on postmenopausal osteoporosis in ovariectomized rats: a meta-analysis and systematic review. Evidence-Based Complementary and Alternative Medicine, 2021(6016874). https://doi.org/10.1155/2021/6016874 Rats, meta-analysis, animal models, systematic reviews, bones, Osteoporosis, osteoporosis, bone formation, naringin, Osteoporosis, Postmenopausal, Postmenopause